Genetic variants for morningness in relation to habitual sleep-wake behavior and diurnal preference in a population-based sample of 17,243 adults

Associations of eveningness with health hazards benefit from analyzing to what extent the polygenic score for morningness correlates assessments behavioral trait morningness-eveningness and chronotype. With a population-based sample 17,243 Finnish adults, aged 25–74 years, this study examines associations four feasible assessment methods chronotype, a) biological genetic liability based on (PGSmorn), b) widely-used single item self-assessed morningness/eveningness (MEQi19) original Morningness-Eveningness Questionnaire (MEQ), c) as assessed shortened version (sMEQ) MEQ, d) phase entrainment habitual midpoint sleep self-reported sleep-wake schedule during weekend (Sleepmid-wknd) well debt corrected (Sleepmid-corr). All self-report measures correlated each other, but very weakly PGSmorn, which explained 1–2% variation in diurnal preference or schedule. The influence age was greater Sleepmid-wknd Sleepmid-corr than sMEQ MEQi19, indicating that might be more stable indicator Analyses discrepancies between MEQi19 indicated can over-estimated when relying only single-item self-assessment. current explains small proportion molecular basis needs further elucidation.